“River Run” begins as Swamp Thing enters the first in a series of fictional worlds created by the mysterious Anna. Transported to a gothic horror version of New Orleans, he encounters Harry Moon, a hard-bitten private eye whose beat includes chasing down vampires, monsters…and Earth Elementals.

In the first story of River Run, City of the Dead, Swamp Thing enters a New Orleans where magic and the occult are part of everyday life. He must help the local law enforcement track down a de-evolving man responsible for a string of murders.

Note: This chapter seems similar to what would be the earth-13 concept in the post-Flashpoint multiverse.